Although neither the boys nor the girls who are survivors of childhood cancer appear to undergo genetic changes that may affect their offspring radiation damage, uterus, it is up to 12 times more likely that children will be born or die shortly after birth, said the researchers.Children who have been treated for cancer have a high probability of long-term recovery, said researcher John Boice Jr., scientific director at the International Institute of Epidemiology, Rockville, Maryland
For more information on childhood cancer, visit the Nemours Foundation.
Women who have survived childhood cancer face an increased risk of having a stillborn child if their uterus and ovaries were exposed to radiation during treatment, according to new research.
At some point, if the child had cancer, you just wanted to know that they were going to live, so you would know that they live well, and now we know that to become healthy adults, Armstrong said.
Effects were noted in this cohort of men exposed to radiation levels in testicular much higher than expected underlying exposure, diagnostic, medical settings or working, the authors of the study.
However, radiation therapy, which included the uterus and ovaries nine times greater risk of stillbirth and infant mortality shortly after birth.
Liu noted, ‘This is a continuation of a series of deep studies in collaboration between Chinese scientists use GIS and population sciences to discover genetic modifiers of human disease., Institute of Shandong Province of Dermatology and Venereology, and Xue-Jun Zhang, MD, Ph. leprae), mainly affects skin and peripheral nerves and can lead to irreversible disability.
Over the past 15 years, each treatment protocol, as far as possible, tried to change our way of delivering radiation therapy, has tried to change the dose, and in some cases, sought to eliminate the radiation does not replace the chemotherapy that is so toxic, Armstrong said.
For the treatment under this [stillbirth] may not be quite the problem as it once was, he said.
When radiation doses were high , the risk of fetal death or neonatal death increased by 12 times, they added.
Armstrong said that over the past 20 years there has been a commitment to improve survival and reduce, if possible, the toxicity and long-term effects of treatment.
For the study, Boice’s team collected data on 1148 men and 1657 women survivors of childhood cancer who were enrolled in the Childhood Cancer Survivor Study, which includes 25 schools in the United States and Canada.
Dr. Daniel Armstrong, Associate Chairman of Pediatrics at the University of Miami Miller School of Medicine, said that on the one hand, it is not a surprising discovery that is based on the known toxicity of radiotherapy.
According to Boice, high doses of radiation can damage the blood flow to the uterus, reducing its size. If this has an effect on the cause or causes other problems associated with stillbirth isn t clear.
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The researchers found that the radiation of the testes in males and females in the pituitary gland, as well as chemotherapy in these areas did not increase the risk of having a child born dead.